quarta-feira, 17 de novembro de 2021

FLASHBACK: Viral (and Scientific) Madness

 


 

Máximo Sandín

2010

A new “scientific advance” has been announced by the media; a new use for antiviral drugs: Treatment “against schizophrenia”. According to the journal Schizophrenia Research (1): “exposure to the common virus that causes cold sores may be partially responsible for the decrease in brain regions and the loss of concentration, memory, coordination of movements and dexterity, largely observed in patients with schizophrenia." The timely appearance of a virus in an apparently deteriorated organ opens a new path for the pharmaceutical industry: These findings could lead to new forms of treatment or prevention of cognitive deterioration "that normally accompany the the disease, including therapy with antiviral drugs", explain the authors. 

Continuing on from the disastrous and indiscriminate war against bacteria, which has led to an unstoppable expansion of bacterial resistance to antibiotics, the fight against viruses has now been unleashed. It seems that the celebrity drugs of the pharmaceutical laboratories for the 21st century will be antivirals. And they have a huge field of application. As we all know, any disease with a confusing diagnosis has been caused by "a virus." Therefore, "you have to fight them." For example, the famous antiretroviral Tamiflu is an inhibitor of the enzyme neuramidase, one of the two “surface antigens” (the other being hemagglutinin) that the influenza virus carries in its capsid. Neurological problems, sometimes very serious, have occurred in children treated with Tamiflu (suicides related to this problem have occurred in Japan) (2). Neuramidase is an enzyme involved in the development and maintenance of the myelin sheath of neurons in mammals (3), so the inhibitory effect is immediate in children (in adults, it takes a little longer...). 

In the human genome, between 90,0000 and 300,0000 sequences derived from viruses have been identified, mainly from retroviruses (4), but there are also DNA viruses. Specifically, the Herpesvirus 6A genome is integrated into the telomeres of human chromosomes (5). The variability of the figures is due to the fact that they depend on whether complete viruses or partial sequences derived from viruses are taken into account. These sequences are "permanent components of the human transcriptome" (6), that is, they are constituent parts of our genome and are expressed in all tissues (6). Even the viral sequences that code for the capsid have been shown to be active in fundamental biological processes (3, 7, 8). Especially abundant and relevant is the activity of sequences of retroviral origin in the process of embryonic development (9), that is, in the formation of our tissues and organs. The coherent inference for these phenomena would be the following: If solid tumors are a trigger for an embryonic process (10, 11) produced by some type of "environmental aggression", the association of viruses with cancer would not be causal, but consequential. Tumors emit viral particles (12). And the association of viruses with damaged or diseased tissues would have the same cause. Truly absurd virus associations have been "diagnosed" in diseases with obvious environmental, degenerative or autoimmune origins, such as chronic fatigue syndrome, arthritis, Alzheimer's, prostate tumor... There has even been a report, without real understanding, of the activation of an endogenous virus as a consequence of treatment with a drug (Natalizumab) for multiple sclerosis, which "awakened a dormant virus in the kidneys" whose "malignancy" triggered a Progressive Multifocal Leukoencephalopathy. 

The war against viruses, unleashed mainly by companies that finance “applied” biological research (that is, research for commercial purposes) has turned nonsensical, completely ignoring the discoveries obtained by “basic research”, that is, true scientific research. The production of vaccines (another big business for these companies) growing viruses in chicken embryos (13) or, the most “modern” of them using cell lines for culture (13), are true factories for hybrid viruses (if not actually “transgenic” vaccines) whose potential dangers can be extremely serious (14, 15, 16). And the insane trend of the use of "antivirals" for all kinds of diseases that are spuriously assigned a viral origin is a new attack on fundamental components of the body, and of life. Every day, an ever greater amount of scientific data shows us that we literally live immersed amidst an inconceivable number of bacteria and viruses (17, 18) that fulfill essential functions in all ecosystems (19, 20) and that have played fundamental roles in the processes of the evolution of life (21, 22), and that their "pathogenic" aspect is the result of some destabilisation of their natural functions. It is a suicidal war against Nature. A war against ourselves.

The true "mental pathology" is the dominant thinking in our concepts about Nature. A conception that has been embedded in the brain of scientists and that sees Nature as a battlefield in which all its components are "competitors". But let's not worry, the big multinational pharmaceutical companies are going to defend us from “our worst competitors”. After the defeat in the fight against bacteria, the fight against viruses has begun. It will be the mother of all battles. And maybe even the final battle?

 

 

REFERENCIAS   

1.- David J. Schretlen, Tracy D. Vannorsdall, Jessica M. Winicki, Yaser Mushtaq,  Takatoshi Hikida, Akira Sawa, Robert H. Yolken, Faith B. Dickerson  and Nicola G.  Cascella. (2010) Neuroanatomic and cognitive abnormalities related to herpes simplex  virus type 1 in schizophrenia. Schizophrenia Research Volume 118, Issues 1-3, May  2010, Pages 224-231.  

2.- Agencia EFE (30/7/2009).  Alta tasa de efectos secundarios en niños que  recibieron Tamiflu contra la gripe A.  

3.- Megumi Saito, Carmen Sato-Bigbee and Robert K. Yu. (2008).  Neuraminidase  Activities in Oligodendroglial Cells of the Rat Brain. Journal of Neurochemistry  Volume 58 Issue 1, Pages 78 – 82.  

4.- Lower, R., J. Lower, and R. Kurth. (1996). The viruses in all of us:  characteristics and biological significance of human endogenous retrovirus sequences.  Proc. Natl. Acad. Sci. U. S. A. 93:5177-5184.  

5.- Arbucklea, J. H. Et al., (2010). The latent human herpesvirus-6A genome  specifically integrates in telomeres of human chromosomes invivo and in vitro. Proc.  Natl. Acad. Sci. U. S. A. www.pnas.org/cgi/doi/10.1073/pnas.0913586107.  

6.- Seifarth, W. et al., (2005). Comprehensive Analysis of Human Endogenous  Retrovirus Transcriptional Activity in Human Tissues with a Retrovirus-Specific  Microarray. J Virol. 2005; 79(1): 341–352.   

7.- Bouton, O., et al. (2004). The endogenous retroviral locus ERVWE1 is a bona  fide gene involved in hominoid placental physiology. PNAS | vol. 101 | no. 6 | 1731- 1736.  

8.- Gabus C. et al., (2001). The prion protein has DNA strand transfer properties  similar to retroviral nucleocapsid protein. J Mol Biol. 6;307(4):1011-1021. 

9.- Andersson, A.- C., et al. (2002). Developmental Expression of HERV-R (ERV3)  and HERV-K in Human Tissue. Virology Volume 297, Issue 2, Pages 220-225   

10.- Kho, A. T. et al., (2004). Conserved mechanisms across development and  tumorigenesis revealed by a mouse development perspective of human cancers. Genes  Dev.; 18(6): 629–640.   

11.- Schuller U., Kho A. Zhao Q., Qiufu Ma., Rowitch DH. (2006) Cerebellar  ‘transcriptome’ reveals cell-type and stage-specific expression during postnatal  development and tumorigenesis. Molecular and Cellular Neuroscience. Volume 33,  Issue 3, 6, Pages 247-259   

12.- Seifarth, W. et al., (1995). Retrovirus-like particles released from the human  breast cancer cell line T47-D display type B- and C-related endogenous retroviral  sequences. J. Virol.,  Vol 69, No. 10, 6408-6416.   

13.-  INTERNATIONAL FEDERATION OF PHARMACEUTICAL AND  MANUFATURERS & ASSOCIATIONS  http://www.ifpma.org/influenza/index.aspx?47  

14.- Khan A. S. et al., (2009). Proposed algorithm to investigate latent and occult  viruses in vaccine cell substrates by chemical induction.  Biologicals. 2009 Mar 17.  [Epub ahead of print].  

15.-  ISIS Report 07/10/09  Flu Vaccines and the Risk of Cancer http://www.i- sis.org.uk/fluVaccinesCancerRisks.php  

16.- Hussain, A. I. (2003).  Identification and Characterization of Avian  Retroviruses in Chicken Embryo-Derived Yellow Fever Vaccines: Investigation of  Transmission to Vaccine Recipients. J Virol. 2003, 77(2): 1105–1111.  

17.- Grice, E. A. et al., (2009). Topographical and Temporal Diversity of the Human  Skin Microbiome. Science 29, Vol. 324. no. 5931, pp. 1190 - 1192   

18.- Williamson, K.E., et al., (2003). Sampling Natural Viral Communities from  Soil for Culture-Independent Analyses. Applied and Environmental Microbiology, Vol.  69, No. 11, p. 6628-6633  

19.- Gewin, V. 2006. Genomics: Discovery in the dirt. Nature .Published online: 25  January 2006; | doi:10.1038/439384a  

20.- Suttle, C. A. (2005). Viruses in the sea. Nature 437, 356-361.  

21.-  Gupta,  R.  S.  2000.  The  natural  evolutionary  relationships  among  prokaryotes.  Crit. Rev. Microbiol. 26: 111-131.    

22.- Villarreal, L. P. (2004). Viruses and the Evolution of Life. ASM Press,  Washington.

 

Source: http://www.somosbacteriasyvirus.com/locura.pdf

Translation: David Montoute 

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